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上海起發(fā)專業(yè)代理并分銷BioPorto糖尿病、肥胖癥等代謝疾病相關(guān)的單克隆抗體。蛋白質(zhì)/多肽類激素通常是產(chǎn)生于特定刺激后分泌到循環(huán)系統(tǒng)中的激素原，一旦分泌，大多數(shù)的肽激素在血液循環(huán)自由存在。在穿越血液循環(huán)的同時，在靶細(xì)胞表面遇到受體，并與特定的內(nèi)分泌細(xì)胞上的細(xì)胞表面受體結(jié)合。內(nèi)分泌細(xì)胞合成，儲存和分泌蛋白質(zhì)/多肽激素，并再次激活各種信號轉(zhuǎn)導(dǎo)系統(tǒng)，內(nèi)分泌的紊亂會引起多種代謝疾病。
糖尿病相關(guān)
胰高血糖素樣肽-1(GLP-1) 存在多種剪切體，包括GLP-1 Extended form、GLP-1 Active form及GLP-1 Metabolite等。BioPorto專業(yè)提供針對各種形式GLP-1的單克隆抗體，用于GLP-1糖尿病治療的研究及檢測，為早期研發(fā)階段、臨床階段I和/或在zui終治療產(chǎn)品的生產(chǎn)和質(zhì)量控制過程提供可靠依據(jù)。
圖1 不同形式的GLP-1 (Glucagon-likepeptide1)示意圖
提供胰高血糖素樣肽-2(GLP-2)、胰多肽(PP)、Exendin-4、胰高血糖素（Glucagon）等糖尿病研究相關(guān)單克隆抗體：
貨號 | 產(chǎn)品名稱 | 規(guī)格 | 宿主 | 應(yīng)用 |
ABS 033-04-02 | Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific) | 200µl | Mouse | ELISA, IHC |
ABS 033-04-1 | Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific) | 1ml | Mouse | ELISA, IHC |
ABS 033-10-02 | Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific) | 200µl | Mouse | ELISA, WB |
ABS 033-10-1 | Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific) | 1ml | Mouse | ELISA, WB |
ABS 033-10B-005 | Glucagon-like peptide-1 (GLP-1(7-37) and GLP-1(7-36)amide, N-terminal specific) | 50µl | Mouse | ELISA |
ABS 044-49-02 | Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific) | 200µl | Mouse | ELISA, WB |
ABS 044-49-1 | Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific) | 1ml | Mouse | ELISA, WB |
ABS 044-53-02 | Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific) | 200µl | Mouse | ELISA, WB |
ABS 044-53-1 | Glucagon-like peptide-1 (GLP-1(9-37) and GLP-1(9-36)amide, N-terminal specific) | 1ml | Mouse | ELISA, WB |
ABS 046-03-02 | Glucagon-like peptide-1 (GLP-1, Non-amidated (-Arg-Gly), C-terminal specific) | 200µl | Mouse | ELISA, WB |
ABS 046-03-1 | Glucagon-like peptide-1 (GLP-1, Non-amidated (-Arg-Gly), C-terminal specific) | 1ml | Mouse | ELISA, WB |
ABS 046-03B-005 | Glucagon-like peptide-1 (GLP-1, Non-amidated (-Arg-Gly), C-terminal specific) | 50µl | Mouse | ELISA |
HYB 011-05-02 | Glucagon-like peptide-1 (GLP-1(1-36)amide, N-terminal-extension specific) | 200µl | Mouse | ELISA, WB |
HYB 011-05-1 | Glucagon-like peptide-1 (GLP-1(1-36)amide, N-terminal-extension specific) | 1ml | Mouse | ELISA, WB |
HYB 147-06-02 | Glucagon-like peptide-1 (GLP-1 (7-36)amide, C-terminal specific) | 200µl | Mouse | ELISA, IHC |
HYB 147-06-1 | Glucagon-like peptide-1 (GLP-1 (7-36)amide, C-terminal specific) | 1ml | Mouse | ELISA, IHC |
HYB 147-06B-005 | Glucagon-like peptide-1 (GLP-1 (7-36)amide, C-terminal specific) | 50µl | Mouse | ELISA |
HYB 147-08-02 | Glucagon-like peptide-1 (GLP-1, Mid-molecule specific) | 200µl | Mouse | ELISA, WB |
HYB 147-08-1 | Glucagon-like peptide-1 (GLP-1, Mid-molecule specific) | 1ml | Mouse | ELISA, WB |
HYB 147-08B-005 | Glucagon-like peptide-1 (GLP-1, Mid-molecule specific) | 50µl | Mouse | ELISA |
HYB 147-12-02 | Glucagon-like peptide-1 (GLP-1, Mid-molecule specific) | 200µl | Mouse | ELISA, WB, IHC |
HYB 147-12-1 | Glucagon-like peptide-1 (GLP-1, Mid-molecule specific) | 1ml | Mouse | ELISA, WB, IHC |
HYB 147-12B-005 | Glucagon-like peptide-1 (GLP-1, Mid-molecule specific) | 50µl | Mouse | ELISA |
HYB 147-13-02 | Glucagon-like peptide-1 (GLP-1, Mid-molecule specific) | 200µl | Mouse | ELISA, WB |
HYB 147-13-1 | Glucagon-like peptide-1 (GLP-1, Mid-molecule specific) | 1ml | Mouse | ELISA, WB |
HYB 006-02-02 | Glucagon-like peptide-2 (human, GLP-2) | 200µl | Mouse | ELISA |
HYB 006-02-1 | Glucagon-like peptide-2 (human, GLP-2) | 1ml | Mouse | ELISA |
ABS 030-06-02 | Pancreatic Polypeptide (human, PP) | 200µl | Mouse | ELISA, WB |
ABS 030-06-1 | Pancreatic Polypeptide (human, PP) | 1ml | Mouse | ELISA, WB |
HYB 347-06-02 | Pancreatic PolyPeptide (PP) | 200µL | Mouse | ELISA |
HYB 347-06-1 | Pancreatic PolyPeptide (PP) | 1ml | Mouse | ELISA |
ABS 012-20-02 | Exendin-4 | 200µl | Mouse | ELISA |
ABS 012-20-1 | Exendin-4 | 1ml | Mouse | ELISA |
ABS 012-24-02 | Exendin-4 | 200µl | Mouse | ELISA |
ABS 012-24-1 | Exendin-4 | 1ml | Mouse | ELISA |
ABS 012-35-02 | Exendin-4 | 200µl | Mouse | ELISA |
ABS 012-35-1 | Exendin-4 | 1ml | Mouse | ELISA |
ABS 012-35B-005 | Exendin-4 | 50µl | Mouse | ELISA |
ABS 058-08-02 | Glucagon (human, pig, rat) | 200µl | Mouse | ELISA |
ABS 058-08-1 | Glucagon (human, pig, rat) | 1ml | Mouse | ELISA |
ABS 058-08B-005 | Glucagon (human, pig, rat) | 50µl | Mouse | ELISA |
ABS 061-09-02 | Glucagon (human, pig, rat) | 200µl | Mouse | ELISA |
ABS 061-09-1 | Glucagon (human, pig, rat) | 1ml | Mouse | ELISA |
CAT.NO. ABS 033-10B
DELIVERY: 1-5 DAYS
Cat. No.
ABS 033-10B
Product name
Anti-GLP-1(7-37) and GLP-1(7-36)amide (N-terminal specific)
Description
Mouse monoclonal antibody, biotinylated
Specificity
ABS 033-10 binds the free N-terminus of GLP-1(7-37) and GLP-1(7-36)amide and shows <0.2% cross-reactivity with GLP-1(9-36)amide, glucagon and human GIP. Cross-reacts 0.25% with GLP-1(1-37), approximay 6% with human GLP-2 and approximay 50% with exendin-4. ABS 033-10 cross-reacts with Liraglutide.聽
Immunogen
Synthetic GLP-1(7-17)聽
Application
Species reactivity (positive)
Human
Species reactivity (negative)
Not determined
Subclass
IgG2a/k
Gene ID
2641
Clone number
10
Epitope
Free N-terminus of GLP-1(7-37) and GLP-1(7-36)amide.
Content
50 碌L, 1 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
Biotinylated
Form
Liquid
Solvent
0.01 M phosphate buffer, pH 7.4, with 0.14 M NaCl and 15 mM sodium azide
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Glucagon-like peptide 1(7-36)amide (GLP-1(7-36)amide) is the principal active form of GLP-1, the other being GLP-1(7-37). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.
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